Stem cells for the first time successfully used for the treatment of stroke – Russian Newspaper

The American scientists have for the first time successfully used stem cells to repair damage in the brain of mice that have arisen as a result of a stroke. This is stated in a scientific paper published in the journal Nature Medicine.

According to experts, if the therapy would be effective in respect of the people, it will allow in the future to accelerate the recovery process insultnikov and patients with other injuries of the nervous tissue, RIA Novosti

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The University of Southern California in Los Angeles were able to find the key to the transformation of stem cells into “adult” brain cells. They also managed to ensure that the cells migrated into the damaged area of ​​the nervous tissue

The body contains “protein C” -. One of the most important proteins that prevents blood clotting in the body and protects it from inflammation and mass cell death due to improper inclusion of apoptosis – cell “program” suicide. As shown by experiments on stem cells, the protein helps the growth of the future “pieces” of the nervous tissue and helps transform them into adult types of nerve cells. However, the main problem lies in the fact that the “protein C” – is the strongest anticoagulant. Therefore, scientists had to conduct many experiments to find a mutant version of the protein, which is almost not changed blood clotting. It is named 3K3A-APC

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The scientists tested the effects of a combination of semi-synthetic analogue of the “protein C” and stem cells in mice that have been artificially induced stroke. The control group of mice were administered only stem cells

It was found that a combination of stem cells and 3K3A-APC accelerated brain restoration of mice -. They have a new neurons and other elements of the nervous tissue replaces dead cells in the damaged areas of the brain.

the next step in the work of scientists will conduct a second test phase, which should test the effect 3K3A-APC to a larger group of animals. In addition, the researchers have filed a petition to conduct clinical trials on human volunteers

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